[爆卦] ivermectin 的機轉研究上了nature的子期

https://www.nature.com/articles/s41429-021-00430-5

原文如上，小弟高一之後就沒在讀生物了，不過英文還是看得懂

就introduction 內容看來，這個藥感覺可以寄與厚望（如果我讀錯了歡迎打臉我），也開?

至於裡面內容到底是什麼，有沒有回答了是不是真的有證實在機轉上，此藥可行，我就看不

稍微翻譯一下我看到覺得讓人興奮的一段好了，完全不負責任翻譯。

Several doctor-initiated clinical trial protocols that aimed to evaluate outcomes, such as reduction in mortality figures, shortened length of intensive care unit stay and/or hospital stay and elimination of the virus with ivermectin use have been registered at the US ClinicalTrials.gov [7].
已經有幾個臨床實驗正式申請，且在進行中，想知道此藥可不可以降低死亡率，待在醫院時間，或是消滅病毒。
Real-time data is also available with a meta-analysis of 55 studies to date.
其中有55個有即時資料
As per data available on 16 May 2021, 100% of 36 early treatment and prophylaxis studies report positive effects (96% of all 55 studies).
早期投藥以及預防有正面效果

Of these, 26 studies show statistically significant improvements in isolation.其中有26個有非常顯著的正面效果

Random effects meta-analysis with pooled effects using the most serious outcome reported 79% and 85% improvement for early treatment and prophylaxis respectively (RR 0.21 [0.11–0.37] and 0.15 [0.09–0.25]).
隨機性分析有正面效果

The results were similar after exclusion based sensitivity analysis: 81% and 87% (RR 0.19 [0.14–0.26] and 0.13 [0.07–0.25]), and after restriction to 29 peer-reviewed studies: 82% and 88% (RR 0.18 [0.11–0.31] and 0.12 [0.05–0.30]).
即使拿到比較不嚴謹的實驗 也有很好的結果

Statistically significant improvements were seen for mortality, ventilation, hospitalization, cases, and viral clearance. 100% of the 17 Randomized Controlled Trials (RCTs) for early treatment and prophylaxis report positive effects, with an estimated improvement of 73% and 83% respectively (RR 0.27 [0.18–0.41] and 0.17 [0.05–0.61]), and 93% of all 28 RCTs.
所謂三期隨機實驗也有很好的效果

These studies are tabulated in Table 1. The probability that an ineffective treatment generated results as positive for the 55 studies to date is estimated to be 1 in 23 trillion (p = 0.000000000000043). The consistency of positive results across a wide variety of cases has been remarkable. It is extremely unlikely that the observed results could have occurred by chance [8].
而且看起來不像是運氣好的結果

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